On the day of AC Milan's birthday (founded by English & Italians) the draw said it's England vs Italy.
Arsenal and Chelsea were handed the toughest possible tasks in the Champions League draw.
The Gunners face Italian champions AC Milan while the Blues meet fellow Serie A side Napoli.
The London clubs are the last remaining Premier League sides in the competition following the exits of Manchester United and Manchester City in the group phase.
But managers Andre Villas-Boas and Arsene Wenger must overcome two difficult opponents if they are to reach the quarter-final stage.
Arsenal club secretary David Miles said: "Everyone has earned the right to get to this stage but nevertheless, we're confident and it's going to be two great games. I would guess it's probably the pick of the round."
Chelsea secretary David Barnard admitted Napoli represented a tough draw for the Blues.
He said: "It will be difficult having seen Napoli when they were in the same group as Man City.
"Unfortunately City are no longer with us which reflects the quality of Napoli."
While Chelsea have never before met Napoli in European competition, they are not an unknown threat for boss Villas-Boas after he worked under Jose Mourinho at Inter Milan.
Barnard added: "It's a new experience for us with this club. Andre has experience in Italy though from when he was with Inter so he know the ins and outs of Napoli."
As group winners both English sides will play away in the first leg, which takes place on February 14/15 and 21/22.
The second leg matches will be played on March 6/7 and 13/14.
CHAMPIONS LEAGUE DRAW IN FULL: Lyon v Apoel FC, Napoli v Chelsea, AC Milan v Arsenal, Basel v Bayern Munich, Bayer Leverkusen v Barcelona, CSKA Moscow v Real Madrid, Zenit St Petersburg v Benfica, Marseille v Inter Milan.
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